We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Asymmetric Synthesis of SCF<sub>3</sub>‐Substituted Alkylboronates by Copper‐Catalyzed Hydroboration of 1‐Trifluoromethylthioalkenes.
- Authors
Kojima, Yuki; Nishii, Yuji; Hirano, Koji
- Abstract
A synthetic method for preparation of optically active trifluoromethylthio (SCF3) compounds by a copper‐catalyzed regio‐ and enantioselective hydroboration of 1‐trifluoromethylthioalkenes with H‐Bpin has been developed. The enantioselective hydrocupration of an in situ generated CuH species and subsequent boration reaction generate a chiral SCF3‐containing alkylboronate, of which Bpin moiety can be further transformed to deliver various optically active SCF3 molecules. Computational studies suggest that the SCF3 group successfully controls the regioselectivity in the reaction.
- Subjects
HYDROBORATION; ASYMMETRIC synthesis; MOIETIES (Chemistry); MOLECULES; COPPER
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 24, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202403337