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- Title
Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology.
- Authors
Bertan Hallacoglu; Richard S. Matulewicz; Harriet J. Paltiel; Horacio Padua; Patricio Gargollo; Glenn Cannon; Ahmad Alomari; Angelo Sassaroli; Sergio Fantini
- Abstract
We present a quantitative near-IR spectroscopy study of the absolute values of oxygen saturation of hemoglobin before and after surgically induced testicular torsion in adult rabbits. Unilateral testicular torsions (0, 540, or 720âdeg) on experimental testes and contralateral sham surgery on control testes are performed in four adult rabbits. A specially designed optical probe for measurements at multiple source-detector distances and a commercial frequency-domain tissue spectrometer are used to measure absolute values of testicular hemoglobin saturation. Our results show: (1) a consistent baseline absolute tissue hemoglobin saturation value of 78±5, (2) a comparable tissue hemoglobin saturation of 77±6after sham surgery, and (3) a significantly lower tissue hemoglobin saturation of 36±2after 540- and 720-degtesticular torsion surgery. Our findings demonstrate the feasibility of performing frequency-domain, multidistance near-IR spectroscopy for absolute testicular oximetry in the assessment of testicular torsion. We conclude that near-IR spectroscopy has potential to serve as a clinical diagnostic and monitoring tool for the assessment of absolute testicular hemoglobin desaturation caused by torsion, with the possibility of serving as a complement to conventional color and spectral Doppler ultrasonography.
- Subjects
NONINVASIVE diagnostic tests; SPERMATIC cord torsion; LABORATORY rabbits; NEAR infrared spectroscopy; PEDIATRIC urology; QUANTITATIVE research; HEMOGLOBINS
- Publication
Journal of Biomedical Optics, 2009, Vol 14, Issue 5, p054027
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3253318