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- Title
Safety of 5% Ponazuril (Toltrazuril sulfone) Oral Suspension and Efficacy against Naturally Acquired Cystoisospora ohioensislike Infection in Beagle Puppies.
- Authors
S. Charles; H. Chopade; D. Ciszewski; R. Arther; T. Settje; C. Reinemeyer
- Abstract
Abstract The safety of 5% ponazuril oral suspension was evaluated in two-week-old Beagle puppies by administration of 250 mg ponazuril/kg for three consecutive days. Exaggerated dosages had no adverse effect on health or pathologic (clinical, gross, micro) indices. In two studies to evaluate the efficacy of ponazuril against naturally acquired C. ohioensis-like infections, Beagle puppies were ranked by oocyst counts, randomly allocated to treatment or control groups, and general health observations and oocyst counts were recorded daily for 14 days post treatment. In study 1, 25 Beagle puppies were allocated to five groups: ponazuril 20 or 30 mg/kg once (day 0) or twice (days 0 and 7) or placebo given twice. One treatment at 30 mg/kg significantly reduced oocyst counts (P
- Subjects
ANTIPROTOZOAL agents; PUPPIES; DISEASES; INFECTION; ANIMAL health
- Publication
Parasitology Research, 2007, Vol 101, Issue s0, p137
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-007-0621-9