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- Title
Improving Outcome after Stroke: Overcoming the Translational Roadblock.
- Authors
Endres, Matthias; Engelhardt, Britta; Koistinaho, Jari; Lindvall, Olle; Meairs, Stephen; Mohr, Jay P.; Planas, Anna; Rothwell, Nancy; Schwaninger, Markus; Schwab, Martin E.; Vivien, Denis; Wieloch, Tadeusz; Dirnagl, Ulrich
- Abstract
Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the ‘Janus-faced’ nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; (3) inflammation and brain-immune-system interaction: inflammation contributes to lesion expansion, but is also instrumental in lesion containment and repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies. Copyright © 2008 S. Karger AG, Basel
- Subjects
BRAIN injuries; REPAIRING; RETROFITTING; SYSTEM downtime; S. Karger AG
- Publication
Cerebrovascular Diseases, 2008, Vol 25, Issue 3, p268
- ISSN
1015-9770
- Publication type
Article
- DOI
10.1159/000118039