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- Title
THE INHIBITION OF CATALASE BY ASCORBIC ACID.
- Authors
Foulkes, E. C.; Lemberg, R.
- Abstract
The ascorbic acid inhibition of catalase is partly reversed by carbon monoxide, by low concentrations of diethyldithiocarbamate, and by high concentrations of phosphate. The inhibition is increased by the addition of copper, and is decreased in solutions with reduced copper content. It is concluded that the presence of copper is required for ascorbic acid inhibition of catalase. There is no evidence for the formation of ferrous catalase in the presence of ascorbic acid and low concentrations of hydrogen peroxide. Possible mechanisms of the inhibition are discussed.
- Subjects
CATALASE; VITAMIN C; DIETHYLDITHIOCARBAMATE; HYDROGEN peroxide; CARBON monoxide
- Publication
Australian Journal of Experimental Biology & Medical Science, 1948, Vol 26, Issue 4, p307
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1948.32