We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DNA Vaccine Encoding the Artificial T-Cell Polyepitope Immunogen of Tick-Borne Encephalitis Virus.
- Authors
Kisakov, D. N.; Antonets, D. V.; Shaburova, E. V.; Kisakova, L. A.; Tigeeva, E. V.; Yakovlev, V. A.; Starostina, E. V.; Borgoyakova, M. B.; Protopopova, E. V.; Svyatchenko, V. A.; Loktev, V. B.; Rudometov, A. P.; Ilyichev, A. A.; Nepomnyashchikh, T. S.; Karpenko, L. I.
- Abstract
A promising approach to the development of new means for preventing infection caused by tick-borne encephalitis virus can be DNA vaccines encoding polyepitope T-cell immunogens. A DNA vaccine pVAX-AG4-ub encoding an artificial polyepitope immunogen that includes cytotoxic and T-helper epitopes from the NS1, NS3, NS5, and E proteins of the tick-borne encephalitis virus has been obtained. The developed construct ensured the synthesis of the corresponding mRNAs in transfected eukaryotic cells. Immunization of mice with pVAX-AG4-ub induced the formation of a virus-specific T-cell response providing 50% protection from lethal infection with the virus.
- Subjects
TICK-borne encephalitis viruses; DNA vaccines; EUKARYOTIC cells; VIRUS diseases; POLYHYDRAMNIOS; T cells
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 176, Issue 1, p72
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05970-4