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- Title
Mitochondrial RNA modification: A novel therapeutic target to combat metastasis.
- Authors
Huang, Shifang; Jiang, Honglu; Huang, Zhen; Li, Yuting; Hu, Haoliang
- Abstract
A recent study published in Cell Biology International explores the potential of targeting mitochondrial RNA modifications as a therapeutic strategy to combat metastasis in late-stage cancers. The study focuses on the role of NSUN3, a mitochondrial RNA methyltransferase, and its involvement in the activation of tumor cell invasion and dissemination. The researchers found that inhibiting NSUN3-dependent RNA modifications can decrease the progression of lymph node metastasis without affecting primary tumor growth. Additionally, the study highlights the potential of antibiotics that inhibit mitochondrial translation as a treatment strategy to prevent cancer metastasis. Overall, this research provides valuable insights into the role of mitochondrial RNA modifications in tumor metastasis and suggests potential therapeutic targets for late-stage cancers.
- Subjects
RNA modification &; restriction; MITOCHONDRIAL RNA; TRANSFER RNA; NON-coding RNA; METASTASIS; LINCRNA; CYTOLOGY
- Publication
Cell Biology International, 2024, Vol 48, Issue 3, p233
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.12124