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- Title
Antiproliferation Effects of Marine-Sponge-Derived Methanol Extract of Theonella swinhoei in Oral Cancer Cells In Vitro.
- Authors
Shiau, Jun-Ping; Chuang, Ya-Ting; Tang, Jen-Yang; Chen, Shu-Rong; Hou, Ming-Feng; Jeng, Jiiang-Huei; Cheng, Yuan-Bin; Chang, Hsueh-Wei
- Abstract
The purpose of this study aimed to assess the antiproliferation effects of methanol extract of T. swinhoei (METS) and explore the detailed responses of oral cancer cells compared to normal cells. METS effectively inhibits the cell proliferation of oral cancer cells but does not affect normal cell viability, exhibiting preferential antiproliferation function. METS exerted more subG1 accumulation, apoptosis induction, cellular and mitochondrial oxidative stress, and DNA damage than normal cells, reverted by oxidative stress inhibitor N-acetylcysteine. This METS-caused oxidative stress was validated to attribute to the downregulation of glutathione. METS activated both extrinsic and intrinsic caspases. DNA double-strand breaks (γH2AX) and oxidative DNA damage (8-hydroxy-2-deoxyguanosine) were stimulated by METS. Therefore, for the first time, this investigation shed light on exploring the functions and responses of preferential antiproliferation of METS in oral cancer cells.
- Subjects
ORAL cancer; DOUBLE-strand DNA breaks; CANCER cell proliferation; INHIBITION of cellular proliferation; ORAL mucosa; DNA damage; CANCER cells
- Publication
Antioxidants, 2022, Vol 11, Issue 10, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11101982