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- Title
Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer.
- Authors
Cordani, Marco; Resines-Urien, Esther; Gamonal, Arturo; Milán-Rois, Paula; Salmon, Lionel; Bousseksou, Azzedine; Costa, Jose Sanchez; Somoza, Álvaro
- Abstract
Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively high concentrations and led to an increase in reactive oxygen species (ROS) in two pancreatic cancer cell lines, PANC-1 and BXPC-3, and this effect was accompanied by a significant reduction in cell viability in the presence of gemcitabine (GEM). Importantly, the tested compounds enhanced the effect of GEM, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mTOR pathway. Although further evaluation in animal-based models of pancreatic cancer is needed, these results open novel avenues for exploring these iron-based materials in biomedicine in general and in pancreatic cancer treatment.
- Subjects
PANCREATIC cancer; REACTIVE oxygen species; CELL lines
- Publication
Antioxidants, 2021, Vol 10, Issue 1, p66
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox10010066