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- Title
Microwave Assisted Synthesis, Characterization of New Heterocyclic Compounds and Evaluation as Anti Breast Cancer.
- Authors
Al-Kaabi, Muntadher M.; Rady Al-Hazam, Hanan A.; H. M., Arwa
- Abstract
A number of new heterocyclic compounds derived from vanillin dimer chalcones were prepared by Claisen–Schmidt Condensation using a microwave as a heat source in base medium as a catalyst. The structures and suggestion mechanisms of reaction of the new products were attributed to elementary and spectroscopic analysis. Additionally, in vitro anticancer compounds activity of (Z1, Z2, Z3, Z7, Z8 and Z9) and all of them showed high inhibition efficiency except (Z2) were evaluated with human breast cancer cell line (Cal51), and compared with stander anticancer drugs, according standard MTT assay. The synthesized heterocyclic compounds were characterized based on the chemical properties of their and spectroscopic data (FTIR, ¹H NMR, 13C MNR and CHN-S).
- Subjects
MICROWAVE devices; HETEROCYCLIC compounds synthesis; BREAST cancer treatment; ORGANIC cyclic compounds; ANTINEOPLASTIC agents
- Publication
Basrah Journal of Science / Magallat Al-Barat Li-L-ulum, 2021, Vol 39, Issue 1, p78
- ISSN
2664-8288
- Publication type
Article
- DOI
10.29072/basjs.202116