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Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis.
Published in:
Journal of Pathology, 2021, v. 255, n. 3, p. 330, doi. 10.1002/path.5774
By:
- Garcia de Vinuesa, Amaya;
- Sanchez‐Duffhues, Gonzalo;
- Blaney‐Davidson, Esmeralda;
- van Caam, Arjan;
- Lodder, Kirsten;
- Ramos, Yolande;
- Kloppenburg, Margreet;
- Meulenbelt, Ingrid;
- van der Kraan, Peter;
- Goumans, Marie‐José;
- ten Dijke, Peter
Publication type:
Article
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells.
Published in:
Cell & Tissue Research, 2021, v. 386, n. 2, p. 309, doi. 10.1007/s00441-021-03498-5
By:
- Rodríguez Ruiz, Alejandro;
- Dicks, Amanda;
- Tuerlings, Margo;
- Schepers, Koen;
- van Pel, Melissa;
- Nelissen, Rob G. H. H.;
- Freund, Christian;
- Mummery, Christine L.;
- Orlova, Valeria;
- Guilak, Farshid;
- Meulenbelt, Ingrid;
- Ramos, Yolande F. M.
Publication type:
Article
Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit‐on‐a‐Chip Model.
Published in:
Advanced Materials Technologies, 2022, v. 7, n. 8, p. 1, doi. 10.1002/admt.202101310
By:
- Tuerlings, Margo;
- Boone, Ilja;
- Eslami Amirabadi, Hossein;
- Vis, Michelle;
- Suchiman, Eka;
- van der Linden, Enrike;
- Hofmann, Sandra;
- Nelissen, Rob;
- den Toonder, Jaap;
- Ramos, Yolande;
- Meulenbelt, Ingrid
Publication type:
Article
Genome-wide assessment of differential roles for p300 and CBP in transcription regulation.
Published in:
Nucleic Acids Research, 2010, v. 38, n. 16, p. 5396, doi. 10.1093/nar/gkq184
By:
- Ramos, Yolande F. M.;
- Hestand, Matthew S.;
- Verlaan, Matty;
- Krabbendam, Elise;
- Ariyurek, Yavuz;
- van Galen, Michiel;
- van Dam, Hans;
- van Ommen, Gert-Jan B.;
- den Dunnen, Johan T.;
- Zantema, Alt;
- ′t Hoen, Peter A. C.
Publication type:
Article
Tissue-specific transcript annotation and expression profiling with complementary next-generation sequencing technologies.
Published in:
Nucleic Acids Research, 2010, v. 38, n. 16, p. e165, doi. 10.1093/nar/gkq602
By:
- Hestand, Matthew S.;
- Klingenhoff, Andreas;
- Scherf, Matthias;
- Ariyurek, Yavuz;
- Ramos, Yolande;
- van Workum, Wilbert;
- Suzuki, Makoto;
- Werner, Thomas;
- van Ommen, Gert-Jan B.;
- den Dunnen, Johan T.;
- Harbers, Matthias;
- 't Hoen, Peter A.C.
Publication type:
Article
The transcriptional landscape of age in human peripheral blood.
Published in:
Scientific Reports, 2015, p. 8570, doi. 10.1038/ncomms9570
By:
- Peters, Marjolein J.;
- Joehanes, Roby;
- Pilling, Luke C.;
- Schurmann, Claudia;
- Conneely, Karen N.;
- Powell, Joseph;
- Reinmaa, Eva;
- Sutphin, George L.;
- Zhernakova, Alexandra;
- Schramm, Katharina;
- Wilson, Yana A.;
- Kobes, Sayuko;
- Tukiainen, Taru;
- Ramos, Yolande F.;
- Göring, Harald H. H.;
- Fornage, Myriam;
- Liu, Yongmei;
- Gharib, Sina A.;
- Stranger, Barbara E.;
- De Jager, Philip L.
Publication type:
Article
Characterizing the secretome of licensed hiPSC-derived MSCs.
Published in:
Stem Cell Research & Therapy, 2022, v. 13, n. 1, p. 1, doi. 10.1186/s13287-022-03117-2
By:
- Ramos, Yolande F. M.;
- Tertel, Tobias;
- Shaw, Georgina;
- Staubach, Simon;
- de Almeida, Rodrigo Coutinho;
- Suchiman, Eka;
- Kuipers, Thomas B.;
- Mei, Hailiang;
- Barry, Frank;
- Murphy, Mary;
- Giebel, Bernd;
- Meulenbelt, Ingrid
Publication type:
Article
CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes.
Published in:
Cartilage, 2023, v. 14, n. 1, p. 67, doi. 10.1177/19476035221144747
By:
- Timmermans, Ritchie G.M.;
- Blom, Arjen B.;
- Bloks, Niek G.C.;
- Nelissen, Rob. G.H.H.;
- van der Linden, Enrike H.M.J.;
- van der Kraan, Peter M.;
- Meulenbelt, Ingrid;
- Ramos, Yolande F.M.;
- van den Bosch, Martijn H.J.
Publication type:
Article
Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study.
Published in:
PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103056
By:
- Ramos, Yolande F. M.;
- den Hollander, Wouter;
- Bovée, Judith V. M. G.;
- Bomer, Nils;
- van der Breggen, Ruud;
- Lakenberg, Nico;
- Keurentjes, J. Christiaan;
- Goeman, Jelle J.;
- Slagboom, P. Eline;
- Nelissen, Rob G. H. H.;
- Bos, Steffan D.;
- Meulenbelt, Ingrid
Publication type:
Article
Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 9, p. 1356, doi. 10.3390/biom11091356
By:
- Ramos, Yolande F. M.;
- Coutinho de Almeida, Rodrigo;
- Lakenberg, Nico;
- Suchiman, Eka;
- Mei, Hailiang;
- Kloppenburg, Margreet;
- Nelissen, Rob G. H. H.;
- Meulenbelt, Ingrid
Publication type:
Article
Mechanical stress and inflammation have opposite effects on Wnt signaling in human chondrocytes.
Published in:
Journal of Orthopaedic Research, 2024, v. 42, n. 2, p. 286, doi. 10.1002/jor.25673
By:
- Timmermans, Ritchie G. M.;
- Blom, Arjen B.;
- Nelissen, Rob G. H. H.;
- Broekhuis, Demiën;
- van der Kraan, Peter M.;
- Meulenbelt, Ingrid;
- van den Bosch, Martijn H. J.;
- Ramos, Yolande F. M.
Publication type:
Article
Inactivation of the p53 pathway in retinoblastoma.
Published in:
Nature, 2006, v. 444, n. 7115, p. 61, doi. 10.1038/nature05194
By:
- Laurie, Nikia A.;
- Donovan, Stacy L.;
- Shih, Chie-Schin;
- Zhang, Jiakun;
- Mills, Nicholas;
- Fuller, Christine;
- Teunisse, Amina;
- Lam, Suzanne;
- Ramos, Yolande;
- Mohan, Adithi;
- Johnson, Dianna;
- Wilson, Matthew;
- Rodriguez-Galindo, Carlos;
- Quarto, Micaela;
- Francoz, Sarah;
- Mendrysa, Susan M.;
- Kiplin Guy, R.;
- Marine, Jean-Christophe;
- Jochemsen, Aart G.;
- Dyer, Michael A.
Publication type:
Article
Identified senescence endotypes in aged cartilage are reflected in the blood metabolome.
Published in:
GeroScience, 2024, v. 46, n. 2, p. 2359, doi. 10.1007/s11357-023-01001-2
By:
- Boone, Ilja;
- Tuerlings, Margo;
- Coutinho de Almeida, Rodrigo;
- Lehmann, Johannes;
- Ramos, Yolande;
- Nelissen, Rob;
- Slagboom, Eline;
- de Keizer, Peter;
- Meulenbelt, Ingrid
Publication type:
Article
A Damaging COL6A3 Variant Alters the MIR31HG‐Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading.
Published in:
Advanced Science, 2024, v. 11, n. 36, p. 1, doi. 10.1002/advs.202400720
By:
- Bloks, Niek GC;
- Harissa, Zainab;
- Mazzini, Giorgia;
- Adkar, Shaunak S;
- Dicks, Amanda R;
- Hajmousa, Ghazaleh;
- Steward, Nancy;
- Koning, Roman I.;
- Mulder, Aat;
- de Koning, Berend B.R.;
- Kloppenburg, Margreet;
- de Almeida, Rodrigo Coutinho;
- Ramos, Yolande FM;
- Guilak, Farshid;
- Meulenbelt, Ingrid
Publication type:
Article
Osmolarity‐Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology.
Published in:
Advanced Science, 2024, v. 11, n. 11, p. 1, doi. 10.1002/advs.202306722
By:
- Govindaraj, Kannan;
- Meteling, Marieke;
- van Rooij, Jeroen;
- Becker, Malin;
- van Wijnen, Andre J.;
- van den Beucken, Jeroen J. J. P.;
- Ramos, Yolande F. M.;
- van Meurs, Joyce;
- Post, Janine N.;
- Leijten, Jeroen
Publication type:
Article
Comparative study of the p53-mdm2 and p53-MDMX interfaces.
Published in:
Oncogene, 1999, v. 18, n. 1, p. 189, doi. 10.1038/sj.onc.1202281
By:
- Böttger, Volker;
- Böttger, Angelika;
- Garcia-Echeverria, Carlos;
- Ramos, Yolande FM;
- van der Eb, Alex J;
- Jochemsen, Aart G;
- Lane, David P
Publication type:
Article
The miRNA-mRNA interactome of murine induced pluripotent stem cell-derived chondrocytes in response to inflammatory cytokines.
Published in:
FASEB Journal, 2020, v. 34, n. 9, p. 11546, doi. 10.1096/fj.202000889R
By:
- Ross, Alison K.;
- de Almeida, Rodrigo Coutinho;
- Ramos, Yolande F. M.;
- Jiehan Li;
- Meulenbelt, Ingrid;
- Guilak, Farshid
Publication type:
Article
Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.
Published in:
Rheumatology, 2023, v. 62, n. 4, p. 1669, doi. 10.1093/rheumatology/keac498
By:
- Almeida, Rodrigo Coutinho de;
- Tuerlings, Margo;
- Ramos, Yolande;
- Hollander, Wouter Den;
- Suchiman, Eka;
- Lakenberg, Nico;
- Nelissen, Rob G H H;
- Mei, Hailiang;
- Meulenbelt, Ingrid
Publication type:
Article
Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants.
Published in:
Rheumatology, 2023, v. 62, n. 2, p. 894, doi. 10.1093/rheumatology/keac272
By:
- Hoolwerff, Marcella van;
- Tuerlings, Margo;
- Wijnen, Imke J L;
- Suchiman, H Eka D;
- Cats, Davy;
- Mei, Hailiang;
- Nelissen, Rob G H H;
- Zwaag, Henrike M J van der Linden–van der;
- Ramos, Yolande F M;
- Almeida, Rodrigo Coutinho de;
- Meulenbelt, Ingrid
Publication type:
Article
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization.
Published in:
Rheumatology, 2023, v. 62, n. 1, p. 360, doi. 10.1093/rheumatology/keac232
By:
- Ruiz, Alejandro Rodríguez;
- Hoolwerff, Marcella van;
- Sprangers, Sara;
- Suchiman, Eka;
- Schoenmaker, Ton;
- Dibbets-Schneider, Petra;
- Bloem, Johan L;
- Nelissen, Rob G H H;
- Freund, Christian;
- Mummery, Christine;
- Everts, Vincent;
- Vries, Teun J de;
- Ramos, Yolande F M;
- Meulenbelt, Ingrid
Publication type:
Article
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
Published in:
Rheumatology, 2023, v. 62, n. 1, p. 457, doi. 10.1093/rheumatology/keac202
By:
- Houtman, Evelyn;
- Tuerlings, Margo;
- Suchiman, H Eka D;
- Lakenberg, Nico;
- Cornelis, Frederique M F;
- Mei, Hailiang;
- Broekhuis, Demiën;
- Nelissen, Rob G H H;
- Almeida, Rodrigo Coutinho de;
- Ramos, Yolande F M;
- Lories, Rik J;
- Cruz, Luis J;
- Meulenbelt, Ingrid
Publication type:
Article
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis.
Published in:
Rheumatology, 2022, v. 61, n. 7, p. 3023, doi. 10.1093/rheumatology/keab826
By:
- Tuerlings, Margo;
- Hoolwerff, Marcella van;
- Bokkum, Jessica M van;
- Suchiman, H Eka D;
- Lakenberg, Nico;
- Broekhuis, Demiën;
- Nelissen, Rob G H H;
- Ramos, Yolande F M;
- Mei, Hailiang;
- Cats, Davy;
- Almeida, Rodrigo Coutinho de;
- Meulenbelt, Ingrid
Publication type:
Article
role of TNFRSF11B in development of osteoarthritic cartilage.
Published in:
Rheumatology, 2022, v. 61, n. 2, p. 856, doi. 10.1093/rheumatology/keab440
By:
- Ruiz, Alejandro Rodríguez;
- Tuerlings, Margo;
- Das, Ankita;
- Almeida, Rodrigo Coutinho de;
- Suchiman, H Eka D;
- Nelissen, Rob G H H;
- Ramos, Yolande F M;
- Meulenbelt, Ingrid
Publication type:
Article
Clock genes for joint health: if we could turn back time.
Published in:
2022
By:
- Ramos, Yolande F M;
- Meulenbelt, Ingrid;
- Meijer, Johanna H
Publication type:
Editorial
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.
Published in:
Rheumatology, 2021, v. 60, n. 3, p. 1166, doi. 10.1093/rheumatology/keaa391
By:
- Almeida, Rodrigo Coutinho de;
- Mahfouz, Ahmed;
- Mei, Hailiang;
- Houtman, Evelyn;
- Hollander, Wouter den;
- Soul, Jamie;
- Suchiman, Eka;
- Lakenberg, Nico;
- Meessen, Jennifer;
- Huetink, Kasper;
- Nelissen, Rob G H H;
- Ramos, Yolande F M;
- Reinders, Marcel;
- Meulenbelt, Ingrid
Publication type:
Article
Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production.
Published in:
Rheumatology, 2019, v. 58, n. 6, p. 1065, doi. 10.1093/rheumatology/key426
By:
- Bosch, Martijn H J van den;
- Ramos, Yolande F M;
- Hollander, Wouter den;
- Bomer, Nils;
- Nelissen, Rob G H H;
- Bovée, Judith V M G;
- Berg, Wim B van den;
- Lent, Peter L E M van;
- Blom, Arjen B;
- Kraan, Peter M van der;
- Meulenbelt, Ingrid
Publication type:
Article
The transcriptional landscape of age in human peripheral blood.
Published in:
Nature Communications, 2015, v. 6, n. 10, p. 8570, doi. 10.1038/ncomms9570
By:
- Peters, Marjolein J.;
- Joehanes, Roby;
- Pilling, Luke C.;
- Schurmann, Claudia;
- Conneely, Karen N.;
- Powell, Joseph;
- Reinmaa, Eva;
- Sutphin, George L.;
- Zhernakova, Alexandra;
- Schramm, Katharina;
- Wilson, Yana A.;
- Kobes, Sayuko;
- Tukiainen, Taru;
- Ramos, Yolande F.;
- Göring, Harald H. H.;
- Fornage, Myriam;
- Liu, Yongmei;
- Gharib, Sina A.;
- Stranger, Barbara E.;
- De Jager, Philip L.
Publication type:
Article
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality.
Published in:
Clinical Epigenetics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13148-024-01759-y
By:
- Hajmousa, Ghazaleh;
- de Almeida, Rodrigo Coutinho;
- Bloks, Niek;
- Ruiz, Alejandro Rodríguez;
- Bouma, Marga;
- Slieker, Roderick;
- Kuipers, Thomas B.;
- Nelissen, Rob G. H. H.;
- Ito, Keita;
- Freund, Christian;
- Ramos, Yolande F. M.;
- Meulenbelt, Ingrid
Publication type:
Article
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Published in:
Clinical Epigenetics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13148-024-01676-0
By:
- Bloks, Niek G. C.;
- Dicks, Amanda;
- Harissa, Zainab;
- Nelissen, Rob G. H. H.;
- Hajmousa, Ghazaleh;
- Ramos, Yolande F. M.;
- de Almeida, Rodrigo Coutinho;
- Guilak, Farshid;
- Meulenbelt, Ingrid
Publication type:
Article
Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.
Published in:
PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0154999
By:
- Bomer, Nils;
- Cornelis, Frederique M. F.;
- Ramos, Yolande F. M.;
- den Hollander, Wouter;
- Lakenberg, Nico;
- van der Breggen, Ruud;
- Storms, Lies;
- Slagboom, P. Eline;
- Lories, Rik J. U.;
- Meulenbelt, Ingrid
Publication type:
Article
RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets.
Published in:
Arthritis & Rheumatology, 2021, v. 73, n. 5, p. 789, doi. 10.1002/art.41600
By:
- Tuerlings, Margo;
- Hoolwerff, Marcella;
- Houtman, Evelyn;
- Suchiman, Eka H. E. D.;
- Lakenberg, Nico;
- Mei, Hailiang;
- Linden, Enrike H. M. J.;
- Nelissen, Rob R. G. H. H.;
- Ramos, Yolande Y. F. M.;
- Coutinho de Almeida, Rodrigo;
- Meulenbelt, Ingrid
Publication type:
Article
Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage.
Published in:
Arthritis & Rheumatology, 2020, v. 72, n. 11, p. 1845, doi. 10.1002/art.41396
By:
- Hoolwerff, Marcella;
- Metselaar, Paula I.;
- Tuerlings, Margo;
- Suchiman, H. Eka D.;
- Lakenberg, Nico;
- Ramos, Yolande F.M.;
- Cats, Davy;
- Nelissen, Rob G.H.H.;
- Broekhuis, Demiën;
- Mei, Hailiang;
- Almeida, Rodrigo Coutinho;
- Meulenbelt, Ingrid
Publication type:
Article
Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage.
Published in:
Arthritis & Rheumatology, 2019, v. 71, n. 4, p. 561, doi. 10.1002/art.40748
By:
- Hollander, Wouter;
- Pulyakhina, Irina;
- Boer, Cindy;
- Bomer, Nils;
- Breggen, Ruud;
- Arindrarto, Wibowo;
- Couthino de Almeida, Rodrigo;
- Lakenberg, Nico;
- Sentner, Thom;
- Laros, Jeroen F. J.;
- 't Hoen, Peter A. C.;
- Slagboom, Eline P. E.;
- Nelissen, Rob G. H. H.;
- Meurs, Joyce;
- Ramos, Yolande F. M.;
- Meulenbelt, Ingrid
Publication type:
Article
Transcriptional Associations of Osteoarthritis-Mediated Loss of Epigenetic Control in Articular Cartilage.
Published in:
Arthritis & Rheumatology, 2015, v. 67, n. 8, p. 2108, doi. 10.1002/art.39162
By:
- den Hollander, Wouter;
- Ramos, Yolande F. M.;
- Bomer, Nils;
- Elzinga, Stefan;
- van der Breggen, Ruud;
- Lakenberg, Nico;
- de Dijcker, Wesley J.;
- Suchiman, H. Eka D.;
- Duijnisveld, Bouke J.;
- Houwing‐Duistermaat, Jeanine J.;
- Slagboom, P. Eline;
- Bos, Steffan D.;
- Nelissen, Rob G. H. H.;
- Meulenbelt, Ingrid
Publication type:
Article
Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis.
Published in:
Current Rheumatology Reports, 2015, v. 17, n. 8, p. 1, doi. 10.1007/s11926-015-0528-x
By:
- Ramos, Yolande;
- Meulenbelt, Ingrid
Publication type:
Article
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis.
Published in:
Rheumatology & Therapy, 2021, v. 8, n. 1, p. 499, doi. 10.1007/s40744-021-00287-y
By:
- Houtman, Evelyn;
- van Hoolwerff, Marcella;
- Lakenberg, Nico;
- Suchiman, Eka H. D.;
- van der Linden-van der Zwaag, Enrike;
- Nelissen, Rob G. H. H.;
- Ramos, Yolande F. M.;
- Meulenbelt, Ingrid
Publication type:
Article
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants.
Published in:
Arthritis Research & Therapy, 2021, v. 23, n. 1, p. 1, doi. 10.1186/s13075-021-02595-8
By:
- Houtman, Evelyn;
- Tuerlings, Margo;
- Riechelman, Janne;
- Suchiman, Eka H. E. D.;
- van der Wal, Robert J. P.;
- Nelissen, Rob G. H. H.;
- Mei, Hailiang;
- Ramos, Yolande F. M.;
- Coutinho de Almeida, Rodrigo;
- Meulenbelt, Ingrid
Publication type:
Article
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.
Published in:
PLoS Genetics, 2016, v. 12, n. 10, p. 1, doi. 10.1371/journal.pgen.1006260
By:
- Castaño-Betancourt, Martha C.;
- Evans, Dan S.;
- Ramos, Yolande F. M.;
- Boer, Cindy G.;
- Metrustry, Sarah;
- Liu, Youfang;
- den Hollander, Wouter;
- van Rooij, Jeroen;
- Kraus, Virginia B.;
- Yau, Michelle S.;
- Mitchell, Braxton D.;
- Muir, Kenneth;
- Hofman, Albert;
- Doherty, Michael;
- Doherty, Sally;
- Zhang, Weiya;
- Kraaij, Robert;
- Rivadeneira, Fernando;
- Barrett-Connor, Elizabeth;
- Maciewicz, Rose A.
Publication type:
Article

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