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- Title
原发灶不明颈部淋巴结转移鳞状细胞癌的临床分析.
- Authors
李诗洲; 何晓光; 林雁; 李玉晓; 杨曦; 王晓雨; 杨声豪
- Abstract
Objective To analyze the clinical characteristics of squamous cell carcinoma with cervical lymph node metastasis of unknown primary (CCUP) focus, explore the prognostic factors, and provide the basis for clinical diagnosis and treatment. Methods The clinical data of 23 patients with CCUP who were admitted to our hospital from September 2018 to December 2020 were reviewed. Lymph node metastasis area, tumor stage, P16+, etc. were used as analysis indicators. Univariate analysis was used to establish Cox risk model to analyze prognostic factors. Results As of the end of follow-up, 19 patients survived and 4 died. There was no correlation between the survival prognosis of patients and the gender, course of disease, history of smoking and alcohol, EBV+, lymph node metastasis area, P16+, and whether the primary tumor was clear, and the difference was not statistically significant (all P > 0.05), but it was related to the age of the patient. Correlation (P = 0.024 < 0.05). In the N stage, the later the N stage, the lower the survival rate. The survival rate of patients with unknown primary tumor was lower and clinically significant, but the difference was not statistically significant. Conclusion The patients with CCUP have a short course of disease, and the level Ⅱ, Ⅲ neck lymph nodes are the most involved. EBV detection, P16 and other immunohistochemical staining are helpful for finding the primary site. The best diagnosis and treatment plan should be selected according to the patient’s condition to reduce tumor recurrence and improve the quality of life.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2022, Vol 43, Issue 7, p80
- ISSN
2095-610X
- Publication type
Article
- DOI
10.12259/j.issn.2095-610X.S20220710