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- Title
脑小血管病患者TCD检测脑血流改变与认知功能障碍的相关性研究.
- Authors
张金枝; 张潇; 刘真真
- Abstract
Objective To explore the relationship between cerebral hemodynamic changes and cognitive dysfunction in patients with cerebral small vessel disease (SVD) .Methods A total of 98 patients with cerebral small vessel disease admitted to our department of neurology fromOctober 2016 to October 2017 were selected for the study and were divided into no cognitive impairment (NCI) group and vascular cognitive impairment of none dementia (VCIND) group according to the test results of cognitive function. The mean blood flow velocity (Vm) and pulsatility index (PI) of middle cerebral artery (MCA) and anterior cerebral artery (ACA) were measured by transcranial Doppler ultrasound (TCD) . The correlation between hemodynamic parameters and Montreal Cognitive Assessment (MoCA) score were analyzed. Results The MoCA total score and the scores of visual space, language, abstraction, memory and orientation in VCIND group were significantly lower than those in NCI group (P<0.05) . There were no significant differences in the Vm values of intracranial MCA and ACA between the two groups(P > 0.05), and the MCA-PI in VCIND group was significantly greater than that in NCI group (P<0.05) . Pearson correlation analysis showed that MCA-PI was negatively correlated with MoCA ( = -0.325,P < 0.05) . Conclusions The changes of cerebral blood flow MCA-PI in patients with SVD are associated with the occurrence of cognitive dysfunction.
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2019, Vol 40, Issue 2, p106
- ISSN
2095-610X
- Publication type
Article