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- Title
In vivo Imaging with a Fundus Camera in a Rat Model of Laser-Induced Choroidal Neovascularization.
- Authors
Cunea, alexander; Meyer, Johanna; Russmann, Christoph; Licha, Kai; Welker, Pia; Holz, Frank G.; Schmitz-Valckenberg, Steffen
- Abstract
Purpose: To investigate the use of imaging and quantitative measurement capabilities of a modified fundus camera in a rat model of laser-induced choroidal neovascularization. Methods: Following induction of experimental choroidal neovascularization, Dark Agouti rats underwent serial in vivo imaging with a fundus camera (FF450plus, Carl Zeiss MediTec, Jena, Germany), including color, reflectance and fluorescence imaging. Results: A custom-made setting allowed high-resolution imaging. Change of fluorescence intensity following intravenous or intravitreal dye injection could be quantitatively monitored over time. Hardware binning resulted in an improved signal-to-noise ratio and a reduction of flash light intensity. Simultaneous fluorescence imaging following injection of two different dendritic polygylcerol sulfate dyes could be demonstrated. Conclusion: This study demonstrates the use and optimizations of a fundus camera for various in vivo imaging modalities in rats. Molecular imaging of the eye may allow for better insights into cellular dysfunction and optimization of therapeutic strategies. © 2013 S. Karger AG, Basel
- Subjects
CHOROID; NEOVASCULARIZATION; LABORATORY rats; FLUORESCENCE angiography; DIAGNOSTIC imaging research
- Publication
Ophthalmologica, 2014, Vol 231, Issue 2, p117
- ISSN
0030-3755
- Publication type
Article
- DOI
10.1159/000355094