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- Title
New insights into the function of Interleukin-25 in disease pathogenesis.
- Authors
Yuan, Qingfang; Peng, Na; Xiao, Fan; Shi, Xiaofei; Zhu, Bo; Rui, Ke; Tian, Jie; Lu, Liwei
- Abstract
Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.
- Subjects
PATHOLOGY; TH2 cells; EPITHELIAL cells; PATHOGENESIS; AUTOIMMUNE diseases
- Publication
Biomarker Research, 2023, Vol 11, Issue 1, p1
- ISSN
2050-7771
- Publication type
Article
- DOI
10.1186/s40364-023-00474-9