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- Title
Association Between Cardiorespiratory Fitness and Risk of Type 2 Diabetes: A Meta-Analysis.
- Authors
Qiu, Shanhu; Cai, Xue; Yang, Bingquan; Du, Ziwei; Cai, Min; Sun, Zilin; Zügel, Martina; Michael Steinacker, Jürgen; Schumann, Uwe
- Abstract
<bold>Objective: </bold>This meta-analysis aimed to (1) quantify the association of cardiorespiratory fitness (CRF) with type 2 diabetes risk in the general population and statin users and (2) investigate the joint effects of CRF and fatness with type 2 diabetes risk.<bold>Methods: </bold>Databases were searched for cohort studies reporting the association between CRF and type 2 diabetes risk. Summary hazard ratios (HRs) were obtained using random-effects models.<bold>Results: </bold>Fifteen studies were included. The HRs of type 2 diabetes for every 1-metabolic equivalent increase in CRF were 0.90 (95% CI: 0.86-0.94) for the general population and 0.92 (95% CI: 0.87-0.97) for statin users, and the HRs were linearly shaped (both Pnonlinearity > 0.40). Compared with the nonstatin cohort, there was an increased risk of type 2 diabetes in statin users with the lowest and moderate CRF categories, but this was not present in the highest CRF category. The HR of type 2 diabetes for overweight/obesity-fit category versus normal weight-fit category was larger than that of the normal weight-unfit category versus the normal weight-fit category (Pinteraction = 0.004).<bold>Conclusions: </bold>There was an inverse and dose-dependent association between CRF and type 2 diabetes risk. High CRF may eliminate the diabetogenic effect from statins, yet decreased body weight index seems superior in preventing type 2 diabetes.
- Subjects
TYPE 2 diabetes; PHYSICAL activity; PHYSICAL fitness; CARDIOVASCULAR diseases; BODY mass index
- Publication
Obesity (19307381), 2019, Vol 27, Issue 2, p315
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22368