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- Title
Antimicrobial Nanostructured Bioactive Coating Based on Fe<sub>3</sub>O<sub>4</sub> and Patchouli Oil for Wound Dressing.
- Authors
Rădulescu, Marius; Andronescu, Ecaterina; Holban, Alina Maria; Vasile, Bogdan Stefan; Iordache, Florin; Mogoantă, Laurenţiu; Mogoşanu, George Dan; Grumezescu, Alexandru Mihai; Georgescu, Mihaela; Chifiriuc, Mariana Carmen
- Abstract
The aim of this study was to develop a biocompatible coating for wound dressings, containing iron oxide nanoparticles functionalized with patchouli essential oil in order to obtain improved antimicrobial properties able to prevent biofilm development and consecutive associated infections. The bioactive coating was prepared by the co-precipitation of a precursor in an alkaline solution of patchouli oil. The prepared surface was characterized by XRD (X ray diffraction), TEM (transmission electron microscopy), SAED (selected area diffraction), SEM (scanning electron microscopy) and FT-IR (Fourier transform infrared spectroscopy). The bioevaluation of the obtained coating consisted in antimicrobial, as well as in vitro and in vivo biocompatibility and biodistribution assays. The obtained coating revealed a strong anti-biofilm activity maintained up to 72 h, as well as a low cytotoxicity on mammalian cells and a good biodistribution after intraperitoneal injection in mice. These results demonstrate the promising potential of the respective coatings for the management of wound infections and for the development of soft materials with improved resistance to microbial colonization.
- Subjects
NANOSTRUCTURES; BIOACTIVE compounds; ANTI-infective agents; SURGICAL dressings; SCANNING electron microscopy
- Publication
Metals (2075-4701), 2016, Vol 6, Issue 5, p103
- ISSN
2075-4701
- Publication type
Article
- DOI
10.3390/met6050103