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- Title
Stromal fibroblast activation and their potential association with uterine fibroids.
- Authors
LI-HUA ZHENG; FENG-FENG CAI; GE, ISABELL; BISKUP, EWELINA; ZHONG-PING CHENG
- Abstract
Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts in tumor microenvironments have emerged as an important target for cancer therapy. Repeated stimulation by infectious or non-infectious agents in the uterine tissues, including inflammation, mechanical forces or hypoxia, stimulate the resident fibroblasts to undergo specific activation and, thus, are significant in tumorigenesis. Furthermore, complex signaling pathways regulate the mechanisms of fibroblastic activation. The current review focuses on the molecular mechanisms of fibroblastic activation and the potential association with uterine leiomyoma pathogenesis, enabling an integrated pathogenic analysis for review of the therapeutic options.
- Subjects
UTERINE fibroid treatment; UTERINE fibroids; DIAGNOSIS of cancer in female reproductive organs; FIBROBLASTS; HYSTERECTOMY; PATIENTS
- Publication
Oncology Letters, 2014, Vol 8, Issue 2, p479
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2014.2225