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- Title
Vasoconstrictor activities and bio-availabilities of seven proprietary corticosteroid creams assessed using a non-occluded multiple dosage regimen; clinical implications.
- Authors
Barry, B. W.; Woodford, R.
- Abstract
The bio-availabilities and activities of commercial creams (Metosyn, Synalar, Betnovate, Locoid, Alphaderm, Dioderm and Efcortelan 1%) were assessed using a multiple dosage regimen vaso- constrictor assay in ten volunteers. The blanching response first increased but then diminished with continued application over a 5-day period: following a 2-day `resting period', when no steroid was applied, the application sites recovered considerably but tachyphylaxis again resulted from subsequent repeated applications. Acute tolerance occurred with the hydrocortisone formulations (Alphaderm, Dioderm and Efcortelan 1 %) in a manner similar to that observed with the potent preparations. Metosyn was significantly more active (<em>P</em><0.05), and Efcortctan 1% was significantly less active (<em>P</em><0.05), than the other formulations. Apart from the reversal of Dioderm and Alphaderm the rank order of preparations was similar to that previously noted in the 6 h occluded single-application vaso-constrictor test. The results may have significance in dosage form design and application for topical corticosteroid formulations.
- Subjects
VASOCONSTRICTORS; HYDROCORTISONE; CARDIOVASCULAR agents; GLUCOCORTICOIDS; DRUGS; DERMATOLOGY
- Publication
British Journal of Dermatology, 1977, Vol 97, Issue 5, p555
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1977.tb14135.x