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- Title
Endoplasmic reticulum stress markers are of no value in predicting cardiopulmonary resuscitation success and survival in out-of hospital cardiac arrest: A nested case-control study.
- Authors
Ardic, Senol; Yilmaz, Sertac; Demir, Selim; Dogramaci, Seniz; Altuntas, Gurkan; Imamoglu, Melih; Mentese, Ahmet; Turedi, Suleyman
- Abstract
Objectives: The purpose of this study was to determine the value of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and PERK in predicting the success of cardiopulmonary resuscitation (CPR) or post-CPR survival. Materials and Methods: Non-traumatic out-of-hospital CA patients were included in this prospective, nested casecontrol study. Standard CPR and post-resuscitative care were applied. Levels of ER stress markers were measured at presentation and were investigated to determine whether they might constitute a marker predicting return of spontaneous circulation (ROSC) or sustained ROSC, and of 24-h, and 1 and 3-month survival. Results: Fifty-two out of 99 non-traumatic CA patients were enrolled. ROSC was determined at a level of 25%, sustained ROSC at 23%, 24-h survival at 7%, and 1- and 3-month survival at 4.6%. No difference was determined in terms of ER stress markers between patients with and without ROSC or sustained ROSC. Only PERK levels were higher in surviving patients than non-surviving subjects in terms of 24-h survival (p=0.01). Otherwise, no stress markers differed between surviving and non-surviving patients at any survival time point. Conclusion: ER stress markers are of no value in determining establishment of ROSC or sustained ROSC, success of CPR, or survival. Only PERK levels may be valuable in terms of 24-h survival.
- Subjects
ENDOPLASMIC reticulum; CARDIOPULMONARY resuscitation; CARDIAC arrest; GLUCOSE-regulated proteins; BYSTANDER CPR; CASE-control method
- Publication
Turkish Journal of Emergency Medicine, 2019, Vol 19, Issue 2, p58
- ISSN
1304-7361
- Publication type
Article
- DOI
10.1016/j.tjem.2018.12.001