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- Title
Inhibitors of purine and pyrimidine synthesis: mycophenolate, azathioprine, and leflunomide.
- Authors
Mimouni, Daniel; Nousari, H. Carlos
- Abstract
The major goal in the treatment of autoimmune blistering diseases has changed from simply keeping the patient alive to suppressing disease while maintaining quality of life and minimizing drug side effects. Researchers and clinicians are constantly seeking steroid-sparing agents that would allow a dose reduction in corticosteroids with no loss of benefit. Purine and pyrimidine base inhibitors are commonly used for this purpose. These drugs act by inhibiting cell division and inducing cell death. The pharmacologic and clinical aspects of azathioprine, mycophenolate mofetil, and leflunomide are discussed in this review.
- Subjects
LEFLUNOMIDE; ADRENOCORTICAL hormones
- Publication
Dermatologic Therapy, 2002, Vol 15, Issue 4, p311
- ISSN
1396-0296
- Publication type
Article
- DOI
10.1046/j.1529-8019.2002.01539.x