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- Title
Genome-Wide Scanning for Signatures of Selection Revealed Candidate Genes Involved in Pelt Quality and Coat Color in the Karakul Sheep Breed in Compared to other Iranian Breeds.
- Authors
Mirzapour-Abibagloo, A.; Hedayat, N.; Khalkhali-Evrigh, R.; Seyedsharifi, R.; Abdi-Benemar, H.; Hassanzadeh, R.; Hussain, A. Tanveer
- Abstract
Karakul (KAR) is one of the resistant sheep breeds to harsh desert conditions, which is also known for its excelent lamb pelt quality. This study was performed to identify the signature of selections in the KAR breed using whole-genome sequencing data (WGS) compared with five other Iranian native sheep. Three methods, including population differentiation index (Fst), nucleotide diversity (π), and cross-population extended haplotype homozygosity (XP-EHH) applied to detect the genomic signature of selection. Data analysis leads to identifying 38 shared genes among three methods as positively selected genes for the KAR breed. The most of mentioned genes were associated with coat color (KIT, DVL3, YPEL3, ERBB4, ZNF451, and CTSO), fat and energy metabolism (GDPD3, STARD13, ZNF106, MAPK3, RGS6, PHYH, AP2M1, SPAG9, DNAH9, NDUFAF6, and ARSK), muscle function (MYOCD and MCTP1), growth (CPNE4), altitude adaptation (DNAH9 and SERGEF), and reproduction (TBX6, PHYH, SPAG9, and ARSK). Based on our results, these candidate genes may have a positive effect on the adaptation of the KAR breed to a desert environment.
- Subjects
ANIMAL coloration; SHEEP breeding; SHEEP breeds; WHOLE genome sequencing; POPULATION differentiation; GENES
- Publication
Iranian Journal of Applied Animal Science, 2024, Vol 14, Issue 1, p57
- ISSN
2251-628X
- Publication type
Article