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- Title
An immunological study in patients with seborrhoeic dermatitis.
- Authors
Bergbrant, I.-M.; Johansson, S.; Robbins, D.; Scheynius, A.; Faergemann, J.; Soderstrom, T.
- Abstract
The humoral and cellular immune-status was studied in 30 patients with seborrhoeic dermatitis. Increased frequencies of natural killer cells were found in 46% of patients. Furthermore, subnormal mitogen stimulation responses were demonstrated in 13 patients, whereas two individuals were found to have very high numbers of activated T lymphocytes in peripheral blood. Higher-than-normal total serum IgG and IgA was observed in 14 and 11 patients, respectively. For nine of 12 patients with skin lesions, dermal perivascular cell infiltrates were seen. The majority of the infiltrating cells reacted with anti-CD4 antibodies. HLA-DR-expressing keratinocytes were found in two biopsies. The study suggests that patients with seborrhoeic dermatitis may have depressed T-cell function. This could have a bearing on their susceptibility to the <em>Pityrosporum ovale</em>-associated dermatitis. The very high frequencies of activated T cells observed in the peripheral blood of two otherwise healthy seborrhoeic individuals suggests that intermittent systemic immune activation may occur. Seborrhoeic dermatitis is a common skin disease. It can be diagnosed by its characteristic red to yellow-brown lesions covered with greasy scales distributed in areas with a high number of sebaceous glands, such as the scalp, face and upper trunk. There is an association between seborrhoeic dermatitis and the lipophilic yeast <em>Pityrosporum ovale</em> but its exact aetiological role is not known. The yeast is a member of the normal cutaneous flora but also the aetiological agent of pityriasis versicolor and <em>Pityrosporum</em> folliculitis. <em>P. ovale</em> can activate complement via the direct and alternative pathways. This may play some part in the induction of inflammation. Serum antibodies against <em>P. ovale</em> have been found in normal individuals. In seborrhoeic dermatitis, both normal and high serum antibody levels have been demonstrated. A cell-mediated immune response to <em>P. ova</em>...
- Subjects
SKIN inflammation; LYMPHOCYTES; DERMATOLOGY
- Publication
Clinical & Experimental Dermatology, 1991, Vol 16, Issue 5, p331
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.1991.tb00395.x