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- Title
The effect of hydroalcoholic extract of cinnamon on the symptoms of morphine withdrawal syndrome in mice.
- Authors
Molekara, Tahereh; Nazari, Mohammad; Rakhshandeh, Hasan; Jarahi, Lida; Forouzanfar, Fatemeh
- Abstract
Objectives: Addiction to opiates such as morphine is one of the most important social problems. Long-term consumption of opiates leads to physical and psychological dependence which makes it very difficult to quit. In Iranian traditional books, cinnamon was suggested to aid with opiate withdrawal. In this study, we tried to assess its effect on morphine withdrawal symptoms. Materials and Methods: In this study, 50 little white mice were addicted to morphine according to the standards. To 40 mice 200 mg/kg, 100mg/kg and 50 mg/kg of hydroalcoholic extract of cinnamon were subcutaneously injected and to 10 mice, clonidine 0.3 mg/kg was subcutaneously injected one hour before the last dose of morphine. Two hours after the last morphine injection, intraperitoneal of 2 mg/kg of naloxone was injected to all mice and they were observed by a person and a camera for 30 minutes to detect morphine withdrawal symptoms. Results: The results of this study showed that the effect of hydroalcoholic extract of cinnamon on three morphine withdrawal symptoms, i.e., stretching, jumping and urination is dose dependent. Moreover, the interventional groups with cinnamon showed no significant difference between themselves and the control group in terms of itching and the number of droppings (p= 0.99). Conclusion: According to the obtained statistical results, more studies are required to detect the possible mechanism of the effect of hydroalcoholic extracts of cinnamon on mice with morphine withdrawal symptoms.
- Subjects
CINNAMON; TREATMENT of drug withdrawal symptoms; MORPHINE
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p99
- ISSN
2228-7930
- Publication type
Article