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- Title
Investigation of Japanese quail ( Coturnix japonica) as a pharmacokinetic model for cockatiels ( Nymphicus hollandicus) and Poicephalus parrots via comparison of the pharmacokinetics of a single intravenous injection of oxytetracycline hydrochloride.
- Authors
Osofsky, A.; Tell, L. A.; Kass, P. H.; Wetzlich, S. E.; Nugent-Deal, J.; Craigmill, A. L.
- Abstract
The purpose of this study was to determine whether Japanese quail ( Coturnix japonica) would serve as a pharmacokinetic animal model for two small companion parrots: cockatiels ( Nymphicus hollandicus) and Poicephalus parrots. Oxytetracycline (OTC) was the pharmacologic agent chosen for this study as it is eliminated primarily by renal glomerular filtration and undergoes minimal metabolism. A single intravenous injection of 20 mg/kg oxytetracycline hydrochloride was administered to the three study groups and blood samples were obtained at 5, 10, 15, and 30 min post-OTC injection as well as 1, 2, 4, 8, 12 and 24 h post-OTC injection. Quantification of plasma OTC was accomplished using a standardized microbial inhibition assay. Naïve-pooled data (NPD) analysis of the plasma concentration–time profile of OTC best fit a two-compartment open model for all three avian species. Noncompartmental analysis of the mean data yielded the following parameters for quail, cockatiels and Poicephalus parrots respectively: λz = 3.14, 4.57, 3.71 h; AUC = 38.9, 42.7, 49.6 μg·h/mL; and Cl = 514, 468, 403 mL/h/kg. Based on the similarity of these pharmacokinetic parameters, it appears that quail could be used as a model species to predict the appropriate OTC dosing regimen for small psittacine birds. A bootstrap procedure was also applied to these sparse data sets for both compartmental and noncompartmental analysis. The bootstrap procedure allowed for the calculation of variability of parameters; however, the estimates of the parameters were very similar to those calculated using the NPD and the data mean values.
- Subjects
OXYTETRACYCLINE; VETERINARY drugs; PHARMACOKINETICS; JAPANESE quail; POICEPHALUS
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2005, Vol 28, Issue 6, p505
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2005.00694.x