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- Title
Environmental factors in non‐syndromic orofacial clefts: A review based on meta‐analyses results.
- Abstract
Non‐syndromic orofacial clefts (NSOFCs) are prevalent birth defects with a complex etiology where several interacting genetic and environmental factors have been observed. This narrative review describes maternal exposures that have been significantly associated with protective effects or risk factors. The statistically significant information reported here was found in meta‐analysis studies, taking advantage of their precision in defining intervention effects and their management of heterogeneity between studies. In addition, I propose a hypothesis explaining the biological basis for the results of the meta‐analyses. This review aims to improve the evidence available in parent counseling, to prevent the occurrence of orofacial clefts by suggesting lifestyle changes.
- Subjects
CLEFT lip -- Risk factors; MATERNAL exposure; COUNSELING; CRANIOFACIAL abnormalities; SYSTEMATIC reviews; CLEFT palate; MOUTH abnormalities; RISK assessment; CLEFT lip; HEALTH behavior; PARENTS; BEHAVIOR modification; DISEASE risk factors
- Publication
Oral Diseases, 2022, Vol 28, Issue 1, p3
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.13880