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- Title
Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors.
- Authors
Mobuchon, Lenha; Houy, Alexandre; Popova, Tatiana; Dayot, Stéphane; Rodrigues, Manuel; Fiévet, Alice; Stern, Marc-Henri; Galut, Michèle; Putterman, Marc; Tick, Sarah; Roman-Roman, Sergio; Mariani, Pascale; Piperno-Neumann, Sophie; Bidard, François-Clément; Gardrat, Sophie; Barnhill, Raymond L.; Cassoux, Nathalie; Servois, Vincent; Rampanou, Aurore; Mouton, Aurore
- Abstract
Metastatic uveal melanoma is a deadly disease with no proven standard of care. Here we present a metastatic uveal melanoma patient with an exceptional high sensitivity to a PD-1 inhibitor associated with outlier CpG>TpG mutation burden, MBD4 germline deleterious mutation, and somatic MBD4 inactivation in the tumor. We identify additional tumors in The Cancer Genome Atlas (TCGA) cohorts with similar hypermutator profiles in patients carrying germline deleterious MBD4 mutations and somatic loss of heterozygosity. This MBD4-related hypermutator phenotype may explain unexpected responses to immune checkpoint inhibitors.
- Subjects
MELANOMA; IMMUNE system; EYE diseases; CANCER research; TUMORS
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-018-04322-5