We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Treatment Trial of Vitamin D Supplementation in Breast-fed Infants: Universal Supplementation Is Not Necessary for Rickets Prevention in Southern Louisiana.
- Authors
Ponnapakkam, Tulasi; Bradford, Elease; Gensure, Robert
- Abstract
This study was conducted to determine if vitamin D supplementation is required to prevent rickets in breast-fed infants. Breast-feeding rates are increasing, and there are concerns about whether the vitamin D content of breast milk is sufficient. There are a few treatment trials of vitamin D supplementation in breast-fed infants; these were conducted in northern climates. The authors therefore performed a prospective clinical trial comparing vitamin D supplementation with placebo as control in southern Louisiana. Blood samples and questionnaires were collected at birth, 2, 4, and 6 months of age. There were no cases of rickets observed, and no differences in alkaline phosphatase levels between groups. Thus, there was no evidence that vitamin D supplementation reduced rickets risk in the authors’ study population. This suggests that the current recommendations for universal vitamin D supplementation of breast-fed infants throughout the United States may need to be revised.
- Subjects
LOUISIANA; RICKETS prevention; THERAPEUTIC use of vitamin D; ALKALINE phosphatase; BREASTFEEDING; CALCIUM; PARATHYROID hormone; PHOSPHORUS; RESEARCH funding; SURVIVAL analysis (Biometry); T-test (Statistics); RANDOMIZED controlled trials
- Publication
Clinical Pediatrics, 2010, Vol 49, Issue 11, p1053
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/0009922810376320