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- Title
Low Bone Mineral Density and High Incidences of Fractures and Vitamin D Deficiency in 52 Pediatric Cancer Survivors.
- Authors
Bilariki, Kalliopi; Anagnostou, Elli; Masse, Virginie; Elie, Caroline; Grill, Jacques; Valteau-Couanet, Dominique; Kalifa, Chantal; Doz, François; Sainte-Rose, Christian; Zerah, Michel; Mascard, Eric; Mosser, Françoise; Ruiz, Jean-Charles; Souberbielle, Jean-Claude; Eladari, Dominique; Brugières, Laurence; Polak, Michel
- Abstract
Objective: To evaluate bone mineral density (BMD), fractures, and vitamin D deficiency in pediatric patients in complete remission of solid tumor; and to identify risk factors for these three abnormalities. Study Design: Data were collected prospectively after completion of cancer treatment. Hormonal and vitamin D deficiencies were treated. The patients were evaluated again 1 year later. Patients: 52 consecutive patients, 30 boys and 22 girls. Among them, 21 completed the second evaluation. Measurements: A clinical examination, nutritional assessment, and laboratory workup were performed. BMD was measured by absorptiometry. Results: Calcium intake was inadequate in 75% of patients and vitamin D reserves were low in 61.5%. BMD was low at the spine in 32.7%, and at the femur in 24% of patients. Spinal and femoral BMD Z-scores correlated significantly with each other. Femoral BMD Z-score showed significant positive correlations with changes in body mass index, urinary calcium/creatinine ratio, and time since treatment completion, and a significant negative correlation with treatment duration. Fractures were noted in 10 patients but were not correlated with BMD. In the 21 re-evaluated patients, no significant improvements were found in calcium intake, vitamin D status, or BMD Z-score. Conclusions: Survivors of childhood solid cancer have high rates of insufficient calcium intake, vitamin D deficiency, low bone mass and fractures. Copyright © 2010 S. Karger AG, Basel
- Subjects
BONE density; BONE fractures in children; CHILDHOOD cancer; CANCER patients; BODY composition; VITAMIN D deficiency; CALCIUM in the body
- Publication
Hormone Research in Paediatrics, 2010, Vol 74, Issue 5, p319
- ISSN
1663-2818
- Publication type
Article
- DOI
10.1159/000313378