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- Title
Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886).
- Authors
Yeh, Yao-Tsung; Lin, Sung-Chun; Lee, Gene-Hsiang; Wen, Zhi-Hong; Hwang, Tsong-Long; Wu, Yu-Jen; Chen, Jih-Jung; Fang, Lee-Shing; Yuan, Mei-Kang; Sung, Ping-Jyun; Sashiwa, Hitoshi
- Abstract
Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.
- Subjects
OCTOCORALLIA; NITRIC-oxide synthases; BIOLOGICAL assay; SOLVENT extraction; PROTEIN expression
- Publication
Marine Drugs, 2021, Vol 19, Issue 3, p130
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19030130