We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb pain.
- Authors
Ho, Kevin K. N.; Skarpsno, Eivind S.; Nilsen, Kristian B.; Ferreira, Paulo H.; Pinheiro, Marina B.; Hopstock, Laila A.; Bakke Johnsen, Marianne; Steingrímsdóttir, Ólöf A.; Nielsen, Christopher S.; Stubhaug, Audun; Simic, Milena
- Abstract
Objectives: To examine the possible bidirectional association between insomnia and comorbid chronic low back pain (LBP) and lower limb pain and to explore whether high-sensitivity C-reactive protein (hsCRP) amplifies these associations. Methods: We calculated adjusted risk ratios (RR) with 95% confidence intervals (CI) for the development of insomnia and mild-to-severe chronic LBP and lower limb pain at 11 years follow-up in participants aged ≥32 years and with hsCRP ≤10 mg/L at baseline in 2007-2008: 3,714 without chronic LBP or lower limb pain (sample 1) and 7,892 without insomnia (sample 2). Results: Compared to participants without chronic pain, participants with comorbid chronic LBP and lower limb pain had a RR of insomnia of 1.37 (95% CI 1.12-1.66). Compared with participants without insomnia, participants with insomnia did not have an increased risk of comorbid chronic LBP and lower limb pain (RR: 1.06, 95% CI 0.76-1.46); however, participants with insomnia had a RR of chronic LBP of 1.20 (95% CI 1.02-1.42). There was no strong amplifying effect of elevated hsCRP (3.00-10.0 mg/L) on these associations. Conclusions: These findings suggest that elevated hsCRP does not amplify the associations between insomnia and mild-to-severe chronic LBP and lower limb pain. Further research using data on the temporal relation between insomnia, chronic pain, and inflammatory responses are required to fully understand the causal pathways.
- Publication
Scandinavian Journal of Pain, 2023, Vol 23, Issue 1, p110
- ISSN
1877-8860
- Publication type
Article
- DOI
10.1515/sjpain-2021-0197