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- Title
Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans.
- Authors
Neupane, Ram P.; Parrish, Stephen M.; Bhandari Neupane, Jayanti; Yoshida, Wesley Y.; Yip, M. L. Richard; Turkson, James; Harper, Mary Kay; Head, John D.; Williams, Philip G.
- Abstract
Several known sesquiterpenoid quinones and quinols (1–9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and absolute configurations were established from density functional theory (DFT) calculations of the GIAO NMR shielding tensors, and advanced Marfey's analysis of the N-MeLeu residue, respectively. Compounds 1 and 3 showed moderate inhibition of β-secretase 1 (BACE1), whereas 1–9 exhibited moderate to potent inhibition of growth of human glioma (U251) cells. Compounds 1–2 and 4–7 were also active against human pancreatic carcinoma (Panc-1) cells.
- Subjects
SPONGES (Invertebrates); POLYKETIDES; DENSITY functional theory; HUMAN growth
- Publication
Marine Drugs, 2019, Vol 17, Issue 7, p423
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17070423