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- Title
Phenalenones from a Marine-Derived Fungus Penicillium sp.
- Authors
Park, Sung Chul; Julianti, Elin; Ahn, Sungjin; Kim, Donghwa; Lee, Sang Kook; Noh, Minsoo; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
- Abstract
Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.
- Subjects
PENICILLIUM; ACETONE; ADIPOGENESIS; ANTI-inflammatory agents; CELL-mediated cytotoxicity
- Publication
Marine Drugs, 2019, Vol 17, Issue 3, p176
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17030176