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- Title
Validation of abnormal glucose metabolism associated with Parkinson's disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging.
- Authors
Jin, Rongbing; Ge, Jingjie; Wu, Ping; Lu, Jiaying; Zhang, Huiwei; Wang, Jian; Wu, Jianjun; Han, Xianhua; Zhang, Weishan; Zuo, Chuantao
- Abstract
Purpose: We previously identified disease-related cerebral metabolic characteristics associated with Parkinson’s disease (PD) in the Chinese population using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging. The present study aims to assess data reproducibility and robustness of the metabolic activity characteristics across independent cohorts. Patients and methods: Forty-eight patients with PD and 48 healthy controls from Chongqing district, in addition to 33 patients with PD and 33 healthy controls from Shanghai district were recruited. Each subject underwent brain 18F-FDG PET/CT imaging in a resting state. Based on the brain images, differences between the groups and PD-related cerebral metabolic activities were graphically and quantitatively evaluated. Results: Both PD patient cohorts exhibited analogous cerebral patterns characterized by metabolic increase in the putamen, globus pallidus, thalamus, pons, sensorimotor cortex and cerebellum, along with metabolic decrease in parieto-occipital areas. Additionally, the metabolic pattern was highly indicative of the disease, with a significant elevation in PD patients compared with healthy controls (p
- Subjects
GLUCOSE metabolism disorders; PARKINSON'S disease patients; FLUORODEOXYGLUCOSE F18; POSITRON emission tomography; NEUROTOXICOLOGY
- Publication
Neuropsychiatric Disease & Treatment, 2018, Vol 14, p1981
- ISSN
1176-6328
- Publication type
Article
- DOI
10.2147/NDT.S167548