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- Title
Clinical Associations of the Risk Alleles of HLA-Cw6 and CCHCR1 WWCC in Psoriasis.
- Authors
Suomela, Sari; Kainu, Kati; Onkamo, Päivi; Tiala, Inkeri; Himberg, Johan; Kosk1nen, Lotta; Snellman, Erna; Karvonen, Seija-Liisa; Karvonen, Jaakko; Uurasmaa, Tutta; Reunala, Timo; Kivekas, Kristiina; Jansen, Christer; En, Päivi Holopain; Elomaa, Outi; Kere, Juha; Saarialho-Kere, Ulpu
- Abstract
The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. The clinical profiling of a small group of patients (n=34) who were HLA-Cw6- but CCHCR1*WWCC positive suggested that no great differences existed between them and HCR-Cw6-patients. HCR+ genotype (as well as Cw6+ genotype) correlated for the first time positively with female sex and, in contrast with previous studies, negatively with disease severity. Presence of psoriatic arthritis was more pronounced in HCR-psoriasis (as well as in Cw6- psoriasis). Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts.
- Subjects
PSORIASIS; SKIN diseases; GENETIC polymorphisms; GENETIC research; CELL proliferation; CELL growth
- Publication
Acta Dermato-Venereologica, 2007, Vol 87, Issue 2, p127
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-0184