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- Title
Serum-Derived Bovine Immunoglobulin Promotes Barrier Integrity and Lowers Inflammation for 24 Human Adults Ex Vivo.
- Authors
Van den Abbeele, Pieter; Kunkler, Charlotte N.; Poppe, Jonas; Rose, Alexis; van Hengel, Ingmar A. J.; Baudot, Aurélien; Warner, Christopher D.
- Abstract
Serum-derived bovine immunoglobulin (SBI) prevents translocation and inflammation via direct binding of microbial components. Recently, SBI also displayed potential benefits through gut microbiome modulation. To confirm and expand upon these preliminary findings, SBI digestion and colonic fermentation were investigated using the clinically predictive ex vivo SIFR® technology (for 24 human adults) that was, for the first time, combined with host cells (epithelial/immune (Caco-2/THP-1) cells). SBI (human equivalent dose (HED) = 2 and 5 g/day) and the reference prebiotic inulin (IN; HED = 2 g/day) significantly promoted gut barrier integrity and did so more profoundly than a dietary protein (DP), especially upon LPS-induced inflammation. SBI also specifically lowered inflammatory markers (TNF-α and CXCL10). SBI and IN both enhanced SCFA (acetate/propionate/butyrate) via specific gut microbes, while SBI specifically stimulated valerate/bCFA and indole-3-propionic acid (health-promoting tryptophan metabolite). Finally, owing to the high-powered cohort (n = 24), treatment effects could be stratified based on initial microbiota composition: IN exclusively stimulated (acetate/non-gas producing) Bifidobacteriaceae for subjects classifying as Bacteroides/Firmicutes-enterotype donors, coinciding with high acetate/low gas production and thus likely better tolerability of IN. Altogether, this study strongly suggests gut microbiome modulation as a mechanism by which SBI promotes health. Moreover, the SIFR® technology was shown to be a powerful tool to stratify treatment responses and support future personalized nutrition approaches.
- Subjects
INFLAMMATION prevention; THERAPEUTIC use of immunoglobulins; CHEMOKINES; BIFIDOBACTERIUM; DIGESTION; RESEARCH funding; SHORT-chain fatty acids; BACTEROIDES; HOMEOSTASIS; IMMUNOGLOBULINS; CATTLE; GUT microbiome; INTESTINAL barrier function; BACTERIAL physiology; PREBIOTICS; COLON (Anatomy); FERMENTATION; CLOSTRIDIA; INULIN; TUMOR necrosis factors; BIOMARKERS
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1585
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111585