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- Title
Vagus Nerve Stimulation: A Potential Therapeutic Role in Childhood Nephrotic Syndrome?
- Authors
Sethna, Christine B.; Merchant, Kumail; Zanos, Stavros; Deutschman, Clifford S.; Datta-Chaudhuri, Timir; Chavan, Sangeeta; Tracey, Kevin J.
- Abstract
In conclusion, results of our pilot study suggest that taVNS therapy may be useful in the prevention of nephrotic syndrome relapses in patients with FRNS and decreased proteinuria in those with noncongenital SRNS. taVNS is a potentially promising, novel, nonpharmacologic, noninvasive, steroid-sparing approach in the experimental treatment of idiopathic nephrotic syndrome in children. Similarly, a study of 16 rheumatoid arthritis patients with high disease activity had lower activity scores after 4 days of taVNS; there was no change in the activity score in 20 patients with low disease activity [[31]]. Future Directions taVNS has several theoretical advantages as an experimental option for nephrotic syndrome therapy in children because it is an at-home, nonpharmacologic modality. taVNS is also a steroid-sparing therapy free of the deleterious side effects of immunosuppressant medications in children with nephrotic syndrome. Keywords: Transcutaneous auricular vagus nerve stimulation; Vagus nerve stimulation; Inflammatory reflex; Pediatrics EN Transcutaneous auricular vagus nerve stimulation Vagus nerve stimulation Inflammatory reflex Pediatrics 290 296 7 05/16/22 20220401 NES 220401 Dear Editor, Idiopathic nephrotic syndrome, which includes minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy, is characterized by proteinuria, hypoalbuminemia, edema, and dyslipidemia.
- Subjects
VAGUS nerve stimulation; FOCAL segmental glomerulosclerosis; NEPHROTIC syndrome; TRANSCUTANEOUS electrical nerve stimulation; WOMEN in science; PARASYMPATHETIC nervous system
- Publication
American Journal of Nephrology, 2022, Vol 53, Issue 4, p290
- ISSN
0250-8095
- Publication type
Article
- DOI
10.1159/000523837