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- Title
Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patients.
- Authors
De Michele, Manuela; d'Amati, Giulia; Leopizzi, Martina; Iacobucci, Marta; Berto, Irene; Lorenzano, Svetlana; Mazzuti, Laura; Turriziani, Ombretta; Schiavo, Oscar G.; Toni, Danilo
- Abstract
The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with acute ischemic stroke (by mechanical thrombectomy) and myocardial infarction. In this pilot study, we could detect SP, but not nucleocapsid protein, on platelets of COVID-19 patients' thrombi. In addition, in all three COVID-19 thrombi analyzed for molecular biology, no SARS-CoV-2 RNA could be detected by real-time polymerase chain reaction. These data could support the hypothesis that free SP, besides the whole virus, may be the trigger of platelet activation and clot formation in COVID-19.
- Subjects
COVID-19; SARS-CoV-2; STROKE patients; MOLECULAR biology; POLYMERASE chain reaction
- Publication
Journal of Hematology & Oncology, 2022, Vol 15, Issue 1, p1
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/s13045-022-01329-w