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- Title
Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity.
- Authors
Huang, Guang-Ying; Can Cui; Wang, Zhi-Peng; Li, Yong-Qiang; Xiong, Li-Xia; Wang, Li-Zhong; Yu, Shu-Jing; Li, Zheng-Ming; Zhao, Wei-Guang
- Abstract
Background: Plant viruses cause many serious plant diseases and are currently suppressed with the simultaneous use of virucides and insecticides. The use of such materials, however, increases the amounts of pollutants in the environment. To reduce environmental contaminants, virucides with insecticidal activity is an attractive option. Results: A series of substituted ferulic acid amide derivatives 7 and the corresponding hydrogenated ferulic acid amide derivatives 13 were synthesized and evaluated for their antiviral and insecticidal activities. The majority of the synthesized compounds exhibited good levels of antiviral activity against the tobacco mosaic virus (TMW), with compounds 7a, 7b and 7d in particular providing higher levels of protective and curative activities against TMV at 500 µg/mL than the control compound ribavirin. Furthermore, these compounds displayed good insecticidal activities against insects with piercing-sucking mouthparts, which can spread plant viruses between and within crops. Conclusions: Two series of ferulic acid derivatives have been synthesized efficiently. The bioassay showed title compounds not only inhibit the plant viral infection, but also prevented the spread of plant virus by insect vectors. These findings therefore demonstrate that the ferulic acid amides represent a new template for future antiviral studies.
- Subjects
FERULIC acid; HYDROGENATION; ANTIVIRAL agent synthesis; ACID derivatives; INSECTICIDAL plants; PLANT viruses; PLANT diseases; TOBACCO mosaic virus
- Publication
Chemistry Central Journal, 2013, Vol 7, Issue 1, p1
- ISSN
1752-153X
- Publication type
Article
- DOI
10.1186/1752-153X-7-33