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- Title
Evidence for Genetic Reassortment between Human Rotaviruses by Full Genome Sequencing of G3P[4] and G2P[4] Strains Co-circulating in India.
- Authors
T. N. Hoa Tran; Toyoko Nakagomi; Osamu Nakagomi
- Abstract
Rotavirus A causes severe diarrhoea in infants and young children worldwide. Many unusual combinations of G and P genotypes haw been observed in rotaviruses circulating in developing countries. Mixed infection of a single individual with more than one strain is a mechanism by which genetic reassortants arc formed with unusual G and P combinations. However, few studies have provided direct evidence for the formation of such unusual strains as a result of co-infection of co-circulating strains. Here, we used full-genome sequencing to reanalyze a G3PJ4] strain (I07EIB) and a G2PJ4] strain (II6E3D) detected in India in 1993 and showed that 107E1B had virtually an identical nucleotide sequence with U6E3D, except the VP7 gene. Phylogcnetie analysis revealed that the 107E1B VP7 gene was of typical human rotavirus origin, with a99 J% nucleotide sequence identity with another Indian G3 VP" gene. Thus, this study provided robust evidence for Sic formation of the G3P
- Subjects
INDIA; ROTAVIRUS diseases; DIARRHEA in infants; GENOMES; PHYLOGENY; NUCLEOTIDES
- Publication
Tropical Medicine & Health, 2013, Vol 41, Issue 1, p13
- ISSN
1348-8945
- Publication type
Article
- DOI
10.2149/tmh.2012-29