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- Title
Synthesis and Antibacterial Activity of N-[2-(2-naphthyl)ethyl]piperazinyl Quinolones.
- Authors
Shafiee, A.; Emami, S.; Ghodsi, S.; Najjari, S.; Sorkhi, M.; Samadi, N.; Faramarzi, M. A.; Foroumadi, A.
- Abstract
A series of N-[2-(2-naphthyl)ethyl]piperazinyl quinolones containing a carbonyl related functional groups (oxo- or oxyimino-) on the ethyl spacer was synthesized and evaluated for antibacterial activity. The synthesis of N-[2-(2-naphthyl)ethyl]piperazinyl quinolones was achieved through the versatile and efficient synthetic route that involved reaction of piperazinyl quinolones with appropriate α-bromoketone or α-bromooxime derivatives. The structures of new compounds were confirmed by elemental analysis, IR and NMR spectra. Antibacterial data indicated that some of the new N-[2-(2-naphthyl)ethyl]piperazinyl quinolones showed good antibacterial activity and modification of the position 8 and N-1 substituent on quinolone ring, and ethyl spacer functionality produced significant changes in activity against Gram-positive and Gram-negative bacteria.
- Subjects
QUINOLONE antibacterial agents; ANTIBACTERIAL agents; ANTI-infective agents; FLUOROQUINOLONES; QUINOLINE; GRAM-negative bacteria; ENTEROBACTERIACEAE; CARBONYL compounds; FRANCISELLA
- Publication
Journal of the Iranian Chemical Society, 2009, Vol 6, Issue 2, p325
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/BF03245841