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- Title
The Behaviour of Serum Survivin in Patients With Lupus Nephritis.
- Authors
Lisboa, Renata Valente; de Oliveira, Fabiola Reis; Quaresma, Thaise Oliveira; de Almeida, Rafael Moura; Ribeiro Oliveira, Rene Donizeti; Junior, Paulo Louzada
- Abstract
Background: Systemic lupus erythematosus (SLE) is a chronic, multi phenotypic, autoimmune inflammatory disease and renal involvement significantly worsens its prognosis. Apoptosis dysregulation plays a key pathogenic role. Survivin, a protein from the apoptosis inhibitors family, has been considered a promising strategy in cancer therapy and evaluated as one of the regulatory pathways in the scenario of immune-mediated disorders. Objective: This study aims to explore survivin behaviour in SLE patients with lupus nephritis (LN), assessing its potential as a therapeutic and prognostic biomarker. Methods: 297 SLE patients were classified based on the American College of Rheumatology (ACR) 1997 criteria, from 2000 to 2015. In a cross-sectional study, the serum level of survivin was measured by an ELISA test and compared between 200 SLE individuals and healthy controls. In a longitudinal cohort, 97 patients with active LN had the concentration of survinin measured, before and after treatment with cyclophosphamide pulse therapy. Results: The serum concentration of survivin was significantly lower in the SLE group than in healthy controls, regardless of concomitant NL or disease activity. The longitudinal evaluation revealed a significant reduction in survivin serum level after treatment. However, survivin rates were not able to discriminate groups that achieved remission from those that maintained nephritis activity. Conclusion: Our study suggests that survivin levels in SLE patients are lower than in the general population. Even so, its use as a biomarker in SLE seems limited, not reflecting disease activity or response to LN treatment, as in other contexts.
- Subjects
LUPUS nephritis; SURVIVIN (Protein); SYSTEMIC lupus erythematosus; COMORBIDITY; DISEASE complications
- Publication
Biomarker Insights, 2022, Vol 17, p1
- ISSN
1177-2719
- Publication type
Article
- DOI
10.1177/11772719221131470