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- Title
Endocannabinoids and Endovanilloids: A Possible Balance in the Regulation of the Testicular GnRH Signalling.
- Authors
Chianese, Rosanna; Ciaramella, Vincenza; Scarpa, Donatella; Fasano, Silvia; Pierantoni, Riccardo; Meccariello, Rosaria
- Abstract
Reproductive functions are regulated both at central (brain) and gonadal levels. In this respect, the endocannabinoid system (eCS) has a very influential role. Interestingly, the characterization of eCS has taken many advantages from the usage of animal models different from mammals. There fore, this review is oriented to summarize the main pieces of evidence regarding eCS coming from the anuran amphibian Rana esculenta, with particular interest to the morphofunctional relationship between eCS and gonadotropin releasing hormone (GnRH). Furthermore, a novel role for endovanilloids in the regulation of a testicular GnRH system will be also discussed.
- Subjects
TRPV cation channels; CANNABINOIDS; LUTEINIZING hormone releasing hormone receptors; CELLULAR signal transduction; GROWTH associated protein-43; EDIBLE frog
- Publication
International Journal of Endocrinology, 2013, p1
- ISSN
1687-8337
- Publication type
Article
- DOI
10.1155/2013/904748