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- Title
Glucose and lipid-related indicators in relation to elevated alanine aminotransferase in a pediatric population.
- Authors
Momeni, Azin; Yazdi, Maryam; Motlagh, Mohammad Esmail; Qorbani, Mostafa; Kelishadi, Roya
- Abstract
To determine the associations between various glucose and lipid-related indicators with elevated alanine aminotransferase (ALT) in pediatric population. We analyzed the cross-sectional data of 3,771 Iranian children and adolescents aged 7–18 years using the fifth survey of a national school–based surveillance program. The predictive power of 11 different glucose and lipid-related indicators for predicting elevated ALT was examined using receiver operating characteristic (ROC) curve. In the total sample non-HDL-C, non-HDL-C/HDL-C, and TC/HDL-C showed the largest area under the curve (AUC) for elevated ALT detection, with 0.731 (cut-off, 129.5 mg/dL), 0.706, and 0.706, respectively. In girls, non-HDL-C had the highest predictive value (AUC, 0.741, cut-off, 129.5 mg/dL). Among boys, non-HDL-C/HDL-C and TC/HDL-C showed the largest AUC of 0.753 with optimum cut-off values of 2.63 and 3.63, respectively. The findings of this study suggest that non-HDL-C, non-HDL-C/HDL-C, and TC/HDL-C can be predictors of elevated ALT in the pediatric population. These indices can be useful in large population-based studies for predicting children and adolescents at risk of fatty liver.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2024, Vol 37, Issue 7, p597
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem-2024-0092