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- Title
Relationship between Sox-2 and Wnt signaling pathway in cervical cancer.
- Authors
WEI Xing; JI Jing; NING Fen-ru; LIU Hai-juan; ZHAO Juan; WANG Yue-ling
- Abstract
Objective: To invetigate the expressons of and relationship between Sox-2 and Wnt signaling pathway in cervical squamous carcinoma. Methods The expressions of Sox-2, β-catenin and C-myc were detected in HeLa, SiHa and C33A, the three cell lines of cervical cancer (CC), by immunohistochemistry (IHC). The expressions of these genes were detected in tissues of normal cervix (30 cases) and cervical squamous carcinoma (43 cases) by IHC. Results ① Sox-2 was expressed in SiHa and C33A, but not in HeLa; β-catenin and C-myc were expressed in HeLa, SiHa and C33A. ② The expressions of Sox-2, β-catenin and C-myc were significantly higher in tissues of cervical squamous carcinoma than in tissues of normal cervix (P<0.05) . The expresiion of Sox-2 in tissues of cervical squamous carcinoma was associated with the histological grade (P = 0. 049), but not with clinical stage, lymph node metastasis or patient age (P >0.05). β-catenin and C-myc expressons were not correlated wth pathological grade, ciinical stage, lymph node metastaiis or paient age (P >0.05). ③ In cervical squamous carcinoma, the expresiion of Sox-2 had a postive correlation with β-catenin expression (P<0.001, R = 0. 567) and with C-myc (P = 0.030, r = 0.331). Conclusion The stem cell marker Sox-2 may be related to the carcinogenesis and progression of cervical carcinoma through the WNT/β-catenin signaling pathway.
- Subjects
SOX transcription factors; WNT proteins; CERVICAL cancer; CELLULAR signal transduction; GENE expression; SQUAMOUS cell carcinoma
- Publication
Journal of Xi'an Jiaotong University (Medical Sciences), 2013, Vol 34, Issue 6, p813
- ISSN
1671-8259
- Publication type
Article
- DOI
10.7652/jdyxb201306023