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- Title
Recurrent Respiratory Infections Revealing CD8α Deficiency.
- Authors
Dumontet, Erwan; Osman, Jennifer; Guillemont-Lambert, Nathalie; Cros, Guilhem; Moshous, Despina; Picard, Capucine
- Abstract
CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.
- Subjects
RESPIRATORY infections; CD8 antigen; CELL-mediated cytotoxicity; MISSENSE mutation; DISEASE relapse; PHENOTYPES; T cells
- Publication
Journal of Clinical Immunology, 2015, Vol 35, Issue 8, p692
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-015-0213-x