We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
- Authors
Strop, Pavel; Delaria, Kathy; Foletti, Davide; Witt, Jody Melton; Hasa-Moreno, Adela; Poulsen, Kris; Casas, Meritxell Galindo; Dorywalska, Magdalena; Farias, Santiago; Pios, Ariel; Lui, Victor; Dushin, Russell; Zhou, Dahui; Navaratnam, Thayalan; Tran, Thomas-Toan; Sutton, Janette; Lindquist, Kevin C; Han, Bora; Liu, Shu-Hui; Shelton, David L
- Abstract
The article discusses a study conducted to investigate the therapeutic effectiveness of antibody drug conjugates (ADCs). Topics discussed include generation of generated site-specific ADCs with high drug loading, examination of in vivo efficacy of higher load ADCs, and evaluation of high load conjugates' safety and tolerability in mice. It concludes that site-specific conjugation can decrease total monoclonal antibody exposure in rat.
- Subjects
THERAPEUTIC use of immunoglobulins; ANTIBODY-drug conjugates; MONOCLONAL antibodies; DRUG dosage; LABORATORY mice
- Publication
Nature Biotechnology, 2015, Vol 33, Issue 7, p694
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.3274