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- Title
Autoantibodies as Biomarkers in Cancer.
- Authors
Pedersen, Johannes W.; Wandall, Hans H.
- Abstract
Circulating autoantibodies produced by the patient's own immune system after exposure to cancer proteins are emerging as promising biomarkers for the early detection of cancer. An advantage of autoantibodies in cancer detection is their production in large quantities, despite the presence of a relatively small amount of the corresponding antigen. Autoantibodies are also expected to have persistent concentrations and long half-lives due to limited proteolysis and clearance from the circulation. Here, we review current methods for the broad screening of cancer-specific autoantibody targets and the use of such targets to develop clinically relevant assays for the detection of cancer
- Subjects
UNITED States; TUMOR diagnosis; AUTOANTIBODIES; GENETICS; IMMUNITY; MEDICAL care; PATIENTS; PEPTIDES; PROTEINS; TUMOR markers; TUMORS; TISSUE arrays
- Publication
Laboratory Medicine, 2011, Vol 42, Issue 10, p623
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LM2T3OU3RZRTHKSN