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- Title
Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia.
- Authors
den Hartog, Ilona; Zwep, Laura B.; Meulman, Jacqueline J.; Hankemeier, Thomas; van de Garde, Ewoudt M. W.; van Hasselt, J. G. Coen
- Abstract
Introduction: Longitudinal biomarkers in patients with community-acquired pneumonia (CAP) may help in monitoring of disease progression and treatment response. The metabolic host response could be a potential source of such biomarkers since it closely associates with the current health status of the patient. Objectives: In this study we performed longitudinal metabolite profiling in patients with CAP for a comprehensive range of metabolites to identify potential host response biomarkers. Methods: Previously collected serum samples from CAP patients with confirmed Streptococcus pneumoniae infection (n = 25) were used. Samples were collected at multiple time points, up to 30 days after admission. A wide range of metabolites was measured, including amines, acylcarnitines, organic acids, and lipids. The associations between metabolites and C-reactive protein (CRP), procalcitonin, CURB disease severity score at admission, and total length of stay were evaluated. Results: Distinct longitudinal profiles of metabolite profiles were identified, including cholesteryl esters, diacyl-phosphatidylethanolamine, diacylglycerols, lysophosphatidylcholines, sphingomyelin, and triglycerides. Positive correlations were found between CRP and phosphatidylcholine (34:1) (cor = 0.63) and negative correlations were found for CRP and nine lysophosphocholines (cor = − 0.57 to − 0.74). The CURB disease severity score was negatively associated with six metabolites, including acylcarnitines (tau = − 0.64 to − 0.58). Negative correlations were found between the length of stay and six triglycerides (TGs), especially TGs (60:3) and (58:2) (cor = − 0.63 and − 0.61). Conclusion: The identified metabolites may provide insight into biological mechanisms underlying disease severity and may be of interest for exploration as potential treatment response monitoring biomarker.
- Subjects
COMMUNITY-acquired pneumonia; CHOLESTERYL ester transfer protein; STREPTOCOCCUS; STREPTOCOCCAL diseases; STREPTOCOCCUS pneumoniae; CALCITONIN; C-reactive protein
- Publication
Metabolomics, 2024, Vol 20, Issue 2, p1
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-024-02091-5