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- Title
Evaluation of antileishmanial activity of plants used in Indian traditional medicine.
- Authors
Sidana, Arushdeep; Farooq, Umar
- Abstract
The present study was aimed at in vitro antileishmanial screening of 10 plants used in the traditional medicine in India. MTT method was used to evaluate the cell death after application of 100, 250, 350 and 500 µg/mL of the methanolic extracts followed by incubation for 24 hours at 25°C. Methanolic leaf extracts of Acorus calamus, Alstonia scholaris and Berberis aristata showed significant antileishmanial activity at a concentration of 500 µg/mL. In order to identify the antileishmanial compounds present in the active extracts of the screened plants, an LC-MS analysis of the tested extracts was carried out. The active extracts revealed the presence of some natural products with known antileishmanial activity along with other compounds. The present study suggests that the active plant extracts may be processed to isolate the compounds that may further be screened for their antileishmanial potential.
- Subjects
LEISHMANIA; PHARMACODYNAMICS; TRADITIONAL medicine; ALSTONIA; LIQUID chromatography-mass spectrometry
- Publication
Bangladesh Journal of Pharmacology, 2015, Vol 10, Issue 2, p423
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v10i2.22674